Improvement in glucose homeostasis per se, in turn, ameliorates oxidative stress, which is a major sequela of chronic hyperglycemia that contributes importantly to the pathogenesis of diabetic complications including nephropathy. The interest in trivalent chromium stems from studies which indicate that chromodulin is capable of binding to the insulin receptor thereby resulting in amplification of insulin signaling chromodulin is a low molecular weight chromium binding substance or a likely product of its metabolism known as the glucose tolerance factor. High-dose Cr(pic)3 treatment mildly improves glycemic control and it causes moderate reduction in albuminuria, without affecting histopathological appearance of the kidney and increasing the risk for DNA damage.Ĭhromium picolinate (Cr(pic)3) is suggested to improve glycemic control in type 2 diabetes. In conclusion, the severely hyperglycemic db/db mouse displays renal structural and functional abnormalities in association with DNA damage. The results generally revealed similar effects to those of the 100 mg/kg diet of the preventional protocol. In interventional protocol, effects of diets containing 0, 100 and 250 mg/kg supplemental chromium, from 12 to 24 weeks of age, were examined in db/db mice. Treatment with Cr(pic)3 did not increase DNA damage despite marked renal accumulation of chromium. High Cr(pic)3 intake (i.e., 100 mg/kg diet) mildly improved glycemic status and albuminuria without affecting blood pressure or creatinine clearance. Creatinine clearance was lower while blood pressure was similar between untreated db/db mice and their db/m controls. Untreated db/db mice displayed increased plasma glucose and insulin, hemoglobin A1c, renal tissue advanced glycation end (AGE) products, albuminuria, glomerular mesangial expansion, urinary 8-hydroxydeoxyguanosine (8-OHdG, an index of oxidative DNA damage) and renal tissue immunostaining for γH2AX (a marker of double-strand DNA breaks) compared to db/m controls. In preventional protocol, male obese diabetic db/db mice were fed diets either lacking or containing 5, 10 or 100 mg/kg chromium as Cr(pic)3 from 6 to 24 weeks of age male lean nondiabetic db/m mice served as controls. This product is not intended to diagnose, treat, cure, or prevent any disease.This study examined renal and glycemic effects of chromium picolinate (Cr(pic)3) supplementation in the context of its purported potential for DNA damage. These statements have not been evaluated by Health Canada or the FDA. Suggested Use:Īdults - Take one or two capsules per day or as directed by a healthcare practitioner Warning:Īs with any natural health product, you should consult a healthcare practitioner prior to use of this product, especially if you are pregnant or breastfeeding. Vegetable-grade magnesium stearate, vegetable capsule, microcrystalline cellulose. Vanadium (vanadyl sulfate) 25 mcg Non-medicinal ingredients DirectionsĪdults - Take one or two capsules per day or as directed by a healthcare practitioner Medicinal IngredientsĬhromium (TRAACS® Chromium Nicotinate Glycinate Chelate) 200 mcg CanPrev Chromium Nicotinate Glycinate 200ĬanPrev’s Chromium Nicotinate Glycinate 200 contains a blend of chromium, glycine and niacin (vitamin B3) and is a superior formulation when it comes to absorption and gentleness.* This particular composition is considered to be one of the safest and most efficient delivery forms of chromium.* When it comes to blood sugar regulation and lipid, carbohydrate, protein and corticosteroid metabolism, chromium is key.* It may also help to reduce the risk of coronary heart disease and diabetes.* Features:Ĭhromium Nicotinate Glycinate 200 provides support for healthy glucose metabolism.
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